PHD BIOSCIENCES

SUPPORTIVE CARE ONCOLOGY

PHD is developing a topical uracil cream (UTC) for capecitabine induced hand foot syndrome (HFS), which has already successfully completed a combined Phase 1-2 study in patients with metastatic breast cancer (mBC) and been granted Fast Track Status by the United States Food and Drug Administration.  The technology is protected by 7 issued and 1 pending patent, and the global market for UTC is estimated to be in excess of $200 million USD annually.  With a recent  $2 million grant award from the National Cancer Institute, we are preparing to initiate a pivotal study in 100 patientrs with mBC. 

SICKLE CELL DISEASE

PHD-14 is  a repurposed small molecule as a chronic oral therapeutic to improve vascular flow, reduce the frequency of pain crises, and ameliorate organ damage in sickle cell patients.  The orally available small molecule is expected to be well tolerated in sickle patients because it was demonstrated to be safe in clinical studies with a total of 460 healthy volunteers and patients from a different indication.

CYSTIC FIBROSIS

Enzyme Inhibitors for Cystic Fibrosis: PHD Biosciences is developing small molecule enzyme inhibitors that operates by a distinct mechanism of action from all known drugs. A single dose causes sustained anti-inflammatory benefits that persist for > 24 h, and are expected to convey benefit to patients.

SKIN CANCER PREVENTION

Skin cancer is the most common form of cancer in the United States. Exposure to ultraviolet (UV) radiation is a known risk factor for the development of skin cancer and health care agencies recommend that sunscreens be used as a preventative measure. A major limitation associated with commercial sunscreens is they contain UV filters that lack affinity with skin and are easily removed by normal wear. Consequently, users must continually reapply sunscreen to gain full benefit. Thus, the development of durable UV filters that provide long-wear protection remains a significant priority. PHD Biosciences has developed titanium dioxide and zinc oxide UV filters that are more substantive with the epidermis than commercially available sunscreens. Our novel sunscreens form temporary, but reversible, covalent bonds with the epidermis, and are expected to alleviate the need for constant product reapplication. These UV filters are readily synthesized from inexpensive materials and exhibit enhanced water-resistance when delivered to human skin, thus providing long-wear protection from UV radiation.

INFO@PHDBIOSCIENCES | 646.801.3872 | 180 VARICK STREET,  SUITE 526, NEW YORK, NY 10014      ©2017 PHDBIOSCIENCES