PHD DERMATOLOGY ASSETS
PHD is developing a line of Over-The-Counter and prescription extrafacial dermatology products that are bioequivalent to commercial products. The PHD products are unique because they utilize our patented Never Miss A Spot (NMAS) extension applicator (see phdskincare.com) to allow for delivery of the treatment formulas to the harder-to-reach areas of the body.
SMALL MOLECULE ANTI-CANCER THERAPEUTICS
PHD Biosciences is developing a library of targeted small molecule anti-cancer therapeutics that selectively disrupt the epigenetic development of cancerous cells causing suppression of primary tumors and dramatic regression of established tumors. This novel approach originated in the laboratory of Professor Vern Schramm at the Albert Einstein College of Medicine, and PHD Biosciences is developing the lead molecules for anti-cancer indications. This project is currently supported by a Phase I Small Business Technology Transfer (STTR) award from the National Cancer Institute, an Avon Foundation for Women award, and three New York State Center for Advanced Technology awards.
Enzyme Inhibitors for Cystic Fibrosis: PHD Biosciences is developing small molecule enzyme inhibitors that operates by a distinct mechanism of action from all known drugs. A single dose causes sustained anti-inflammatory benefits that persist for > 24 h, and are expected to convey benefit to patients.
SKIN CANCER PREVENTION
Skin cancer is the most common form of cancer in the United States. Exposure to ultraviolet (UV) radiation is a known risk factor for the development of skin cancer and health care agencies recommend that sunscreens be used as a preventative measure. A major limitation associated with commercial sunscreens is they contain UV filters that lack affinity with skin and are easily removed by normal wear. Consequently, users must continually reapply sunscreen to gain full benefit. Thus, the development of durable UV filters that provide long-wear protection remains a significant priority. PHD Biosciences has developed titanium dioxide and zinc oxide UV filters that are more substantive with the epidermis than commercially available sunscreens. Our novel sunscreens form temporary, but reversible, covalent bonds with the epidermis, and are expected to alleviate the need for constant product reapplication. These UV filters are readily synthesized from inexpensive materials and exhibit enhanced water-resistance when delivered to human skin, thus providing long-wear protection from UV radiation.
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